Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

Piche, T.; Barbara, Giovanni; Aubert, P.; Bruley des Varannes, Stanislas; Dainese, Raffaella; Nano, J.L.; Cremon, Cesare; Stanghellini, Vincenzo; De Giorgio, Roberto; Galmiche, Jean–Paul; Neunlist, Michel

doi:10.1136/gut.2007.140806

Public

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

Published in Gut • Sep 29, 2008

Authors:

T. Piche

Giovanni Barbara

P. Aubert

Abstract

BACKGROUND: Growing evidence suggests that patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. We aimed to investigate (1) paracellular permeability in colonic biopsies of pati...

Subject

Paracellular transport

Irritable bowel syndrome

Occludin

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