Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B.

SJ, Hadziyannis; NC, Tassopoulos; EJ, Heathcote; TT, Chang; G, Kitis; M, Rizzetto; P, Marcellin; SG, Lim; Z, Goodman; MS, Wulfsohn; S, Xiong; J, Fry; CL, Brosgart

doi:10.1056/nejmoa021812

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Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B.

Shared by NobleBlocks on Feb 1, 2003 • 12:00 AM UTC

Authors:

Hadziyannis SJ

Tassopoulos NC

Heathcote EJ

Abstract

Background Adefovir dipivoxil, a nucleotide analogue, demonstrated clinically significant antiviral activity in patients with chronic hepatitis B in phase 1 and 2 clinical trials.Methods We randomly assigned 185 patients with chronic hepatitis B who were negative for hepatitis B e antigen (HBeAg) to...

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