Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man

Barnes, Eleanor; Folgori, Antonella; Capone, Stefania; Swadling, Leo; Aston, Stephen; Kurioka, Ayako; N. Meyer, Joel; Huddart, R.; Smith, Kira; Townsend, Rachel; Brown, Anthony; Antrobus, Richard; Ammendola, Virginia; Naddeo, Mariarosaria; O’Hara, Geraldine; B. Willberg, Christian; Harrison, Abby; Grazioli, Fabiana; Luisa Esposito, Maria; Siani, Loredana; Traboni, Cinzia; Htun Oo, Ye; Adams, David; V. S. Hill, Adrian; Colloca, Stefano; Nicosia, Alfredo; Cortese, Riccardo; Klenerman, Paul

doi:10.1126/scitranslmed.3003155

Public

Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man

Published in Science Translational Medicine • Jan 4, 2012

Authors:

Eleanor Barnes

Antonella Folgori

Stefania Capone

Abstract

Currently, no vaccine exists for hepatitis C virus (HCV), a major pathogen thought to infect 170 million people globally. Many studies suggest that host T cell responses are critical for spontaneous resolution of disease, and preclinical studies have indicated a requirement for T cells in protection...

Subject

Virology

Heterologous

Hepatitis C virus

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