CD1d-Restricted and TCR-Mediated Activation of V <sub>α</sub> 14 NKT Cells by Glycosylceramides

Kawano, Tetsu; Cui, Junqing; Koezuka, Yasuhiko; Toura, Isao; Kaneko, Yoshikatsu; Motoki, Kazuhiro; Ueno, Hitomi; Nakagawa, Ryusuke; Sato, Hiroshi; Kondo, Eisuke; Koseki, Haruhiko; Taniguchi, Masaru

doi:10.1126/science.278.5343.1626

Public

CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides

Published in Science • Nov 28, 1997

Authors:

Tetsu Kawano

Junqing Cui

Yasuhiko Koezuka

Abstract

Natural killer T (NKT) lymphocytes express an invariant T cell antigen receptor (TCR) encoded by the Valpha14 and Jalpha281 gene segments. A glycosylceramide-containing alpha-anomeric sugar with a longer fatty acyl chain (C26) and sphingosine base (C18) was identified as a ligand for this TCR. Glyco...

Subject

CD1D

T-cell receptor

Natural killer T cell

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!