Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

Cleynen, Isabelle; Boucher, Gabrielle; Jostins, Luke; Philip Schumm, L.; Zeißig, Sebastian; Ahmad, Tariq; Andersen, Vibeke; M. Andrews, Jane; Annese, Vito; Brand, Stephan; R. Brant, Steven; H. Cho, Judy; J. Daly, Mark; C. Dubinsky, Marla; H. Duerr, Richard; R. Ferguson, Lynnette; Franke, André; B. Gearry, Richard; Goyette, Philippe; Håkonarson, Håkon; Halfvarson, Jonas; R. Hov, Johannes; Huang, H; A. Kennedy, Nicholas; Kupčinskas, Limas; C. Lawrance, Ian; Lee, James; Satsangi, Jack; Schreiber, S; Théâtre, Emilie; E. van der Meulen‐de Jong, Andrea; K. Weersma, Rinse; C. Wilson, David; Parkes, Miles; Vermeire, Séverine; D. Rioux, John; Mansfield, John; S. Silverberg, Mark; Radford‐Smith, Graham; McGovern, Dermot; C. Barrett, Jeffrey; W. Lees, Charlie

doi:10.1016/s0140-6736(15)00465-1

Public

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

Published in The Lancet • Oct 23, 2015

Authors:

Isabelle Cleynen

Gabrielle Boucher

Luke Jostins

Abstract

BACKGROUND: Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been determined by this binary categorisation. Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared betwee...

Subject

Ulcerative colitis

Phenotype

Crohn's disease

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