Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients

Ciarimboli, Giuliano; S. Lancaster, Cynthia; Schlatter, Eberhard; M. Franke, Ryan; A. Sprowl, Jason; Pavenstädt, Hermann; Massmann, Vivian; Guckel, Denise; H.J. Mathijssen, Ron; Yang, Wenjian; Pui, Ching‐Hon; V. Relling, Mary; Herrmann, Edwin; Sparreboom, Alex

doi:10.1158/1078-0432.ccr-11-2503

Public

Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients

Published in Clinical Cancer Research • Jan 6, 2012

Authors:

Giuliano Ciarimboli

Cynthia S. Lancaster

Eberhard Schlatter

Abstract

PURPOSE: Knowledge of transporters responsible for the renal secretion of creatinine is key to a proper interpretation of serum creatinine and/or creatinine clearance as markers of renal function in cancer patients receiving chemotherapeutic agents. EXPERIMENTAL DESIGN: Creatinine transport was stud...

Subject

Creatinine

Organic cation transport proteins

Renal function

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