Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

J. Anderson, Ethan; E. Lustig, Mary; E. Boyle, Kristen; Woodlief, Tracey; A. Kane, Daniel; Lin, Chien‐Te; W. Price, Jesse; Kang, Li; S. Rabinovitch, Peter; H. Szeto, Hazel; A. Houmard, Joseph; N. Cortright, Ronald; H. Wasserman, David; Darrell Neufer, P.

doi:10.1172/jci37048

Public

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Published in Journal of Clinical Investigation • Feb 2, 2009

Authors:

Ethan J. Anderson

Mary E. Lustig

Kristen E. Boyle

Abstract

High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been implicated in the disease process, but the underlying mechanisms are still unknown....

Subject

Mitochondrion

Insulin resistance

Oxidative stress

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