Genomic responses in mouse models poorly mimic human inflammatory diseases.

Seok, Junhee; Shaw Warren, H; G Cuenca, Alex; N Mindrinos, Michael; V Baker, Henry; Xu, Weihong; R Richards, Daniel; P McDonald-Smith, Grace; Gao, Hong; Hennessy, Laura; C Finnerty, Celeste; M López, Cecilia; Honari, Shari; E Moore, Ernest; P Minei, Joseph; Cuschieri, Joseph; E Bankey, Paul; L Johnson, Jeffrey; Sperry, Jason; B Nathens, Avery; R Billiar, Timothy; A West, Michael; G Jeschke, Marc; B Klein, Matthew; L Gamelli, Richard; S Gibran, Nicole; H Brownstein, Bernard; Miller-Graziano, Carol; E Calvano, Steve; H Mason, Philip; Perren Cobb, J; G Rahme, Laurence; F Lowry, Stephen; V Maier, Ronald; L Moldawer, Lyle; N Herndon, David; W Davis, Ronald; Xiao, Wenzhong; G Tompkins, Ronald; and Host Response to Injury, Large Scale Collaborative Research Program, Inflammation

doi:10.1073/pnas.1222878110

Public

Genomic responses in mouse models poorly mimic human inflammatory diseases.

Published in Proceedings of the National Academy of Sciences of the United States of America • Feb 26, 2013

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Authors:

Junhee Seok

,

H Shaw Warren

,

Alex G Cuenca

Abstract

A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry new drug candidates forward into clinical trials. Systematic studies evaluating how well murine models m...

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