Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects.

C, Borg; M, Terme; J, Taïeb; C, Ménard; C, Flament; C, Robert; K, Maruyama; H, Wakasugi; E, Angevin; K, Thielemans; Cesne A, Le; V, Chung-Scott; V, Lazar; I, Tchou; F, Crépineau; F, Lemoine; J, Bernard; JA, Fletcher; A, Turhan; JY, Blay; A, Spatz; JF, Emile; MC, Heinrich; S, Mécheri; T, Tursz; L, Zitvogel

doi:10.1172/jci21102

Public

Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects.

Shared by NobleBlocks on Aug 1, 2004 • 12:00 AM UTC

Authors:

Borg C

Terme M

Taïeb J

Abstract

Mutant isoforms of the KIT or PDGF receptors expressed by gastrointestinal stromal tumors (GISTs) are considered the therapeutic targets for STI571 (imatinib mesylate; Gleevec), a specific inhibitor of these tyrosine kinase receptors. Case reports of clinical efficacy of Gleevec in GISTs lacking the...

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