Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

Kikkawa, Ushio; Takai, Yoshimi; Tanaka, Yasushi; Miyake, Ryohei; Nishizuka, Yasutomi

doi:10.1016/s0021-9258(17)44245-1

Public

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

Published in Journal of Biological Chemistry • Oct 1, 1983

Authors:

Ushio Kikkawa

Yoshimi Takai

Yasushi Tanaka

Abstract

A tumor-promoting phorbol ester, [3H]phorbol-12,13-dibutyrate, may bind to a homogeneous preparation of Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C) in the simultaneous presence of Ca2+ and phospholipid. This tumor promoter does not bind simply to phospholipid nor to the ...

Subject

Protein kinase C

PRKCQ

Diacylglycerol kinase

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!