<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Li, Jing; Yen, Clifford; Liaw, Danny; Podsypanina, Katrina; Bose, Shikha; I. Wang, Steven; Puc, Janusz; Miliaresis, Christa; Rodgers, Linda; Richard McCombie, W.; H. Bigner, Sandra; C. Giovanella, Beppino; Ittmann, Michael; Tycko, Ben; Hibshoosh, Hanina; Wigler, Michael; Parsons, Ramon

doi:10.1126/science.275.5308.1943

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PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Published in Science • Mar 28, 1997

Authors:

Jing Li

Clifford Yen

Danny Liaw

Abstract

Mapping of homozygous deletions on human chromosome 10q23 has led to the isolation of a candidate tumor suppressor gene, PTEN, that appears to be mutated at considerable frequency in human cancers. In preliminary screens, mutations of PTEN were detected in 31% (13/42) of glioblastoma cell lines and ...

Subject

PTEN

Tensin

Cancer research

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