<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Guillermo Paez, J.; A. Jänne, Pasi; C. Lee, Jeffrey; Tracy, Sean; Greulich, Heidi; Gabriel, Stacey; Herman, Paula; J. Kaye, Frederic; I. Lindeman, Neal; J. Boggon, Titus; Naoki, Katsuhiko; Sasaki, Hidefumi; Fujii, Yoshitaka; J. Eck, Michael; R. Sellers, William; E. Johnson, Bruce; Meyerson, Matthew

doi:10.1126/science.1099314

Public

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Published in Science • May 3, 2004

Authors:

J. Guillermo Paez

Pasi A. Jänne

Jeffrey C. Lee

Abstract

Receptor tyrosine kinase genes were sequenced in non-small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGFR were found in 15of 58 unselected tumors from Japan and 1 of 61 from the United States. Treatment with the EGFR kinase inh...

Subject

Gefitinib

Lung cancer

Epidermal growth factor receptor

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