Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum

Inoue, Takuya; Ho Wang, Joon; Higashiyama, Masaaki; Rudenkyy, Sergiy; Higuchi, Kazuhide; H. Guth, Paul; Engel, Eli; D. Kaunitz, Jonathan; Akiba, Yasutada

doi:10.1152/ajpgi.00195.2012

Public

Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum

Published in American Journal of Physiology-Gastrointestinal and Liver Physiology • Jul 21, 2012

Authors:

Takuya Inoue

Joon Ho Wang

Masaaki Higashiyama

Abstract

Intestinal endocrine cells release gut hormones, including glucagon-like peptides (GLPs), in response to luminal nutrients. Luminal L-glutamate (L-Glu) and 5'-inosine monophosphate (IMP) synergistically increases duodenal HCO3- secretion via GLP-2 release. Since L cells express the bile acid recepto...

Subject

Secretion

Duodenum

Bicarbonate

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