A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

K. Al‐Hilaly, Youssra; L. Williams, Thomas; Stewart-Parker, Maris; Ford, Lenzie; Skaria, Eldhose; Cole, Michael; Grant Bucher, William; L. Morris, Kyle; Sada, Alaa; R. Thorpe, Julian; C. Serpell, Louise

doi:10.1186/2051-5960-1-83

Public

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

Published in Acta Neuropathologica Communications • Dec 1, 2013

Authors:

Youssra K. Al‐Hilaly

Thomas L. Williams

Maris Stewart-Parker

Abstract

BACKGROUND: Alzheimer's disease (AD) is characterized by the deposition of insoluble amyloid plaques in the neuropil composed of highly stable, self-assembled Amyloid-beta (Aβ) fibrils. Copper has been implicated to play a role in Alzheimer's disease. Dimers of Aβ have been isolated from AD brain an...

Subject

Oxidative stress

Fibril

Chemistry

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