A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

Pigeon, Christelle; P. Ilyin, Gennady; Courselaud, Brice; Leroyer, Patricia; Turlin, Bruno; Brissot, Pierre; Loréal, Olivier

doi:10.1074/jbc.m008923200

Public

A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

Published in Journal of Biological Chemistry • Mar 1, 2001

Authors:

Christelle Pigeon

Gennady P. Ilyin

Brice Courselaud

Abstract

Considering that the development of hepatic lesions related to iron overload diseases might be a result of abnormally expressed hepatic genes, we searched for new genes up-regulated under the condition of iron excess. By suppressive subtractive hybridization performed between livers from carbonyl ir...

Subject

Molecular biology

Complementary DNA

Hepcidin

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