Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.

C, Berlioz-Torrent; BL, Shacklett; L, Erdtmann; L, Delamarre; I, Bouchaert; P, Sonigo; MC, Dokhelar; R, Benarous

doi:10.1128/jvi.73.2.1350-1361.1999

Public

Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins.

Shared by NobleBlocks on Feb 1, 1999 • 12:00 AM UTC

Authors:

Berlioz-Torrent C

Shacklett BL

Erdtmann L

Abstract

The cytoplasmic domains of the transmembrane (TM) envelope proteins (TM-CDs) of most retroviruses have a Tyr-based motif, YXXO, in their membrane-proximal regions. This signal is involved in the trafficking and endocytosis of membrane receptors via clathrin-associated AP-1 and AP-2 adaptor complexes...

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