Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita

P. Alter, Blanche; M. Baerlocher, Gabriela; A. Savage, Sharon; J. Chanock, Stephen; B. Weksler, Babette; P. Willner, Judith; A. Peters, June; Giri, Neelam; M. Lansdorp, Peter

doi:10.1182/blood-2007-02-075598

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Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita

Shared by NobleBlocks on Sep 1, 2007 • 12:00 AM UTC

Authors:

Blanche P. Alter

Gabriela M. Baerlocher

Sharon A. Savage

Abstract

Abstract Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome in which the known susceptibility genes (DKC1, TERC, and TERT) belong to the telomere maintenance pathway; patients with DC have very short telomeres. We used multicolor flow fluorescence in situ hybridization analysis...

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