Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

Caspi, Avshalom; Sugden, Karen; E. Moffitt, Terrie; Taylor, Alan; Craig, Ian; Harrington, HonaLee; L. McClay, Joseph; Mill, Jonathan; Martin, Judy; W. Braithwaite, Antony; Poulton, Richie

doi:10.1126/science.1083968

Public

Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene

Published in Science • Jul 17, 2003

Authors:

Avshalom Caspi

Karen Sugden

Terrie E. Moffitt

Abstract

In a prospective-longitudinal study of a representative birth cohort, we tested why stressful experiences lead to depression in some people but not in others. A functional polymorphism in the promoter region of the serotonin transporter (5-HT T) gene was found to moderate the influence of stressful ...

Subject

Serotonin transporter

Moderation

Depression (economics)

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!