Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana

C. Thigpen, Michael; Kebaabetswe, Poloko; Paxton, Lynn; K. Smith, Dawn; E. Rose, Charles; Segolodi, Tebogo; L. Henderson, Faith; Pathak, Sonal; Soud, Fatma; Chillag, Kata; Mutanhaurwa, Rodreck; Ian Chirwa, Lovemore; Kasonde, Michael; S. Abebe, Daniel; Buliva, Evans; Gvetadze, Roman; Johnson, Sandra; Sukalac, Thom; Thomas, Vasavi; E. Hart, Clyde; A. Johnson, Jeffrey; Kevin Malotte, C.; W. Hendrix, Craig; T. Brooks, John

doi:10.1056/nejmoa1110711

Public

Antiretroviral Preexposure Prophylaxis for Heterosexual HIV Transmission in Botswana

Published in New England Journal of Medicine • Jul 11, 2012

Authors:

Michael C. Thigpen

Poloko Kebaabetswe

Lynn Paxton

Abstract

BACKGROUND: Preexposure prophylaxis with antiretroviral agents has been shown to reduce the transmission of human immunodeficiency virus (HIV) among men who have sex with men; however, the efficacy among heterosexuals is uncertain. METHODS: We randomly assigned HIV-seronegative men and women to rece...

Subject

Medicine

Emtricitabine

Placebo

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