Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

Takeshita, S; Zheng, Long; Brogi, Edi; Kearney, Marianne; Q Pu, L; Bunting, S; Ferrara, Napoleone; F Symes, J; M. Isner, Jeffrey

doi:10.1172/jci117018

Public

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

Published in Journal of Clinical Investigation • Feb 1, 1994

Authors:

S Takeshita

Long Zheng

Edi Brogi

Abstract

Vascular endothelial growth factor (VEGF) is a heparin-binding, endothelial cell-specific mitogen. Previous studies have suggested that VEGF is a regulator of naturally occurring physiologic and pathologic angiogenesis. In this study we investigated the hypothesis that the angiogenic potential of VE...

Subject

Medicine

Angiogenesis

Vascular endothelial growth factor

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