Hematopoietic prostaglandin D 2 synthase controls the onset and resolution of acute inflammation through PGD 2 and 15-deoxyΔ 12–14 PGJ 2

Rajakariar, Ravindra; Hilliard, Mark; Lawrence, Toby; Trivedi, Seema; Colville‐Nash, Paul; Bellingan, Geoff; J. Fitzgerald, Desmond; Yaqoob, Muhammad; W. Gilroy, Derek

doi:10.1073/pnas.0707394104

Public

Hematopoietic prostaglandin D 2 synthase controls the onset and resolution of acute inflammation through PGD 2 and 15-deoxyΔ 12–14 PGJ 2

Published in Proceedings of the National Academy of Sciences • Dec 5, 2007

Authors:

Ravindra Rajakariar

Mark Hilliard

Toby Lawrence

Abstract

Hematopoietic prostaglandin D(2) synthase (hPGD(2)S) metabolizes cyclooxygenase (COX)-derived PGH(2) to PGD(2) and 15-deoxyDelta(12-14) PGJ(2) (15d-PGJ(2)). Unlike COX, the role of hPGD(2)S in host defense is ambiguous. PGD(2) can be either pro- or antiinflammatory depending on disease etiology, whe...

Subject

Inflammation

Haematopoiesis

Resolution (logic)

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