Phase III Multicenter Randomized Trial of Oxaliplatin Added to Chronomodulated Fluorouracil–Leucovorin as First-Line Treatment of Metastatic Colorectal Cancer

Giacchetti, Sylvie; Perpoint, B; Zidani, Rachid; Le Bail, N; Faggiuolo, R.; Focan, C.; Chollet, P.; Llory, J; Letourneau, Yves; Coudert, Bruno; Bertheaut-Cvitkovic, F.; Larregain-Fournier, D; Le Rol, A.; D. Walter, Stephen; Adam, R.; Misset, J.L.; Lévi, Françis

doi:10.1200/jco.2000.18.1.136

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Phase III Multicenter Randomized Trial of Oxaliplatin Added to Chronomodulated Fluorouracil–Leucovorin as First-Line Treatment of Metastatic Colorectal Cancer

Published in Journal of Clinical Oncology • Jan 1, 2000

Authors:

Sylvie Giacchetti

B Perpoint

Rachid Zidani

Abstract

PURPOSE: To study how adding oxaliplatin (l-OHP) to chronomodulated fluorouracil (5-FU)-leucovorin (LV) affected the objective response rate, as first-line treatment of metastatic colorectal cancer. PATIENTS AND METHODS: Two hundred patients from 15 institutions in four countries were randomly assig...

Subject

Medicine

Oxaliplatin

Fluorouracil

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