Isolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle Tick

Macedo‐Ribeiro, Sandra; Almeida, Carla; M. Calisto, Bárbara; Friedrich, Thomas; Mentele, Reinhard; Stürzebecher, Jörg; Fuentes‐Prior, Pablo; José Barbosa Pereira, Pedro

doi:10.1371/journal.pone.0001624

Public

Isolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle Tick

Published in PLoS ONE • Feb 20, 2008

Authors:

Sandra Macedo‐Ribeiro

Carla Almeida

Bárbara M. Calisto

Abstract

Inhibitors of coagulation factors from blood-feeding animals display a wide variety of structural motifs and inhibition mechanisms. We have isolated a novel inhibitor from the cattle tick Boophilus microplus, one of the most widespread parasites of farm animals. The inhibitor, which we have termed b...

Subject

Thrombin

Plasmin

Serine Proteinase Inhibitors

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