Connexin 43 Inhibition Sensitizes Chemoresistant Glioblastoma Cells to Temozolomide.

F Murphy, Susan; T Varghese, Robin; Lamouille, Samy; Guo, Sujuan; J Pridham, Kevin; Kanabur, Pratik; M Osimani, Alyssa; Sharma, Shaan; Jourdan, Jane; M Rodgers, Cara; R Simonds, Gary; G Gourdie, Robert; Sheng, Zhi

doi:10.1158/0008-5472.can-15-1286

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Connexin 43 Inhibition Sensitizes Chemoresistant Glioblastoma Cells to Temozolomide.

Shared by NobleBlocks on Jan 1, 2016 • 12:00 AM UTC

Authors:

Susan F Murphy

Robin T Varghese

Samy Lamouille

Abstract

Resistance of glioblastoma (GBM) to the front-line chemotherapeutic agent temozolomide (TMZ) continues to challenge GBM treatment efforts. The repair of TMZ-induced DNA damage by O-6-methylguanine-DNA methyltransferase (MGMT) confers one mechanism of TMZ resistance. Paradoxically, MGMT-deficient GBM...

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