Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4 <sup>+</sup> T Cells

Zhang, Z.-Q.; Schuler, Troy; Zupancic, Mary; W. Wietgrefe, Stephen; A Staskus, K; A. Reimann, Keith; A. Reinhart, Todd; Rogan, Michael; Cavert, Winston; J. Miller, C.; S. Veazey, Ronald; W. Notermans, Daan; J. Little, Susan; A. Danner, S.; D. Richman, Douglas; V. Havlir, Diane; K. Wong, Joseph; L. Jordan, Holly; W. Schacker, Timothy; Rácz, Paul; Tenner‐Racz, Klara; L. Letvin, Norman; M. Wolinsky, Steven; T. Haase, Ashley

doi:10.1126/science.286.5443.1353

Public

Sexual Transmission and Propagation of SIV and HIV in Resting and Activated CD4 + T Cells

Published in Science • Nov 12, 1999

Authors:

Z.-Q. Zhang

Troy Schuler

Mary Zupancic

Abstract

In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4(+) T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in acti...

Subject

Human immunodeficiency virus (HIV)

Transmission (telecommunications)

Sexual behavior

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