Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation

Le Poul, Emmanuel; Loison, Cécile; Struyf, Sofie; Springael, Jean–Yves; Lannoy, Vincent; Decobecq, Marie-Eve; Brézillon, Stéphane; Dupriez, Vincent; Vassart, Gilbert; Van Damme, Jo; Parmentier, Marc; Detheux, Michel

doi:10.1074/jbc.m301403200

Public

Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation

Published in Journal of Biological Chemistry • Jul 1, 2003

Authors:

Emmanuel Le Poul

Cécile Loison

Sofie Struyf

Abstract

Short chain fatty acids (SCFAs), including acetate, propionate, and butyrate, are produced at high concentration by bacteria in the gut and subsequently released in the bloodstream. Basal acetate concentrations in the blood (about 100 microm) can further increase to millimolar concentrations followi...

Subject

Butyrate

Receptor

Chemotaxis

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