Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils

We describe a full structural model for amyloid fibrils formed by the 40-residue β-amyloid peptide associated with Alzheimer's disease (Aβ 1–40 ), based on numerous constraints from solid state NMR and electron microscopy. This model applies specifically to fibrils with a periodically twisted morpho... View More