Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

G. Feagan, Brian; Rutgeerts, Paul; E. Sands, Bruce; B. Hanauer, Stephen; Colombel, Jean‐Frédéric; J. Sandborn, William; Van Assche, Gert; Axler, Jeffrey; Jong Kim, Hyo; Danese, Silvio; H. Fox, Irving; Milch, Catherine; Sankoh, Serap; Wyant, Tim; Xu, Jing; Parikh, Asit

doi:10.1056/nejmoa1215734

Public

Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis

Published in New England Journal of Medicine • Aug 21, 2013

Authors:

Brian G. Feagan

Paul Rutgeerts

Bruce E. Sands

Abstract

BACKGROUND: Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute effective treatment for ulcerative colitis. METHODS: We conducted two integrated randomized, double-blind, placebo-controlled trials of vedolizumab in patients with active disease. In the trial of induction th...

Subject

Vedolizumab

Ulcerative colitis

Induction therapy

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