Accumulation of Aspartic Acid<sup>421</sup>- and Glutamic Acid<sup>391</sup>-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

Basurto‐Islas, Gustavo; Luna‐Muñoz, José; Guillozet-Bongaarts, Angela; I. Binder, Lester; Mena, Raúl; García‐Sierra, Francisco

doi:10.1097/nen.0b013e31817275c7

Public

Accumulation of Aspartic Acid421- and Glutamic Acid391-Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer Disease

Published in Journal of Neuropathology & Experimental Neurology • May 1, 2008

Authors:

Gustavo Basurto‐Islas

José Luna‐Muñoz

Angela Guillozet-Bongaarts

Abstract

Truncations of tau protein at aspartic acid421 (D421) and glutamic acid391 (E391) residues are associated with neurofibrillary tangles (NFTs) in the brains of Alzheimer disease (AD) patients. Using immunohistochemistry with antibodies to D421- and E391-truncated tau (Tau-C3 and MN423, respectively),...

Subject

Entorhinal cortex

Neurofibrillary tangle

Tau protein

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