Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

M. Krawczyk, Przemek; Eppink, Berina; Essers, Jeroen; Stap, Jan; M. Rodermond, Hans; Odijk, Hanny; N. Zelensky, Alex; van Bree, Chris; J.A. Stalpers, Lukas; R. Buist, Marrije; Soullié, Thomas; A.P. Rens, Joost; J.M. Verhagen, Hence; J. O’Connor, Mark; A.P. Franken, Nicolaas; L.M. ten Hagen, Timo; Kanaar, Roland; A. Aten, Jacob

doi:10.1073/pnas.1101053108

Public

Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

Published in Proceedings of the National Academy of Sciences • May 9, 2011

Authors:

Przemek M. Krawczyk

Berina Eppink

Jeroen Essers

Abstract

Defective homologous recombination (HR) DNA repair imposed by BRCA1 or BRCA2 deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP)-1 inhibition and is currently exploited in clinical treatment of HR-deficient tumors. Here we show that mild hyperthermia (41-42.5 °C) induces degradation o...

Subject

Poly ADP ribose polymerase

Homologous recombination

Polymerase

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