Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

Kardon, Adam; Polgár, Erika; Hachisuka, Junichi; M. Snyder, Lindsey; Cameron, Darren; Savage, Sinead; Cai, Xiaoyun; Karnup, Sergei; R. Fan, Christopher; M. Hemenway, Gregory; S. Bernard, Carcha; S. Schwartz, Erica; Nagase, Hiroshi; Schwarzer, Christoph; Watanabe, Masahiko; Furuta, Takahiro; Kaneko, Takeshi; Richard Koerber, H.; J. Todd, Andrew; E. Ross, Sarah

doi:10.1016/j.neuron.2014.02.046

Public

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

Published in Neuron • Apr 10, 2014

Authors:

Adam Kardon

Erika Polgár

Junichi Hachisuka

Abstract

Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for minutes to hours. However, the neural basis for this effect is unclear, and the underlying neuromodulatory mechanisms are unknown. Previous studies revealed that Bhlhb5(-/-) mice, which lack a specifi...

Subject

Dynorphin

Spinal cord

Dorsum

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