Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture

L. Tulloch, Nathaniel; Muskheli, Veronica; V. Razumova, Maria; Steven Korte, F.; Regnier, Michael; D. Hauch, Kip; Pabon, Lil; Reinecke, Hans; E. Murry, Charles

doi:10.1161/circresaha.110.237206

Public

Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture

Published in Circulation Research • May 20, 2011

Authors:

Nathaniel L. Tulloch

Veronica Muskheli

Maria V. Razumova

Abstract

RATIONALE: The developing heart requires both mechanical load and vascularization to reach its proper size, yet the regulation of human heart growth by these processes is poorly understood. OBJECTIVE: We seek to elucidate the responses of immature human myocardium to mechanical load and vascularizat...

Subject

Tissue engineering

Stem cell

Muscle hypertrophy

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