mtDNA mutations increase tumorigenicity in prostate cancer

A. Petros, John; K. Baumann, Amanda; Ruiz‐Pesini, Eduardo; B. Amin, Mahul; Sun, Carrie; C. Hall, John; Lim, So-Dug; M. Issa, Muta; Dana Flanders, W.; Hamzeh Hosseini, Seyed; F. Marshall, Fray; C. Wallace, Douglas

doi:10.1073/pnas.0408894102

Public

mtDNA mutations increase tumorigenicity in prostate cancer

Published in Proceedings of the National Academy of Sciences • Jan 12, 2005

Authors:

John A. Petros

Amanda K. Baumann

Eduardo Ruiz‐Pesini

Abstract

Mutations in the mtDNA have been found to fulfill all of the criteria expected for pathogenic mutations causing prostate cancer. Focusing on the cytochrome oxidase subunit I (COI) gene, we found that 11-12% of all prostate cancer patients harbored COI mutations that altered conserved amino acids (me...

Subject

Heteroplasmy

Biology

Prostate cancer

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