TP53 Mutations and Survival in Squamous-Cell Carcinoma of the Head and Neck

Luana Poeta, Maria; Manola, Judith; A. Goldwasser, Meredith; A. Forastiere, Arlene; Benoit, Nicole; A. Califano, Joseph; A. Ridge, John; Goodwin, Jarrard; E. Kenady, Daniel; Saunders, John; H. Westra, William; Sidransky, David; M. Koch, Wayne

doi:10.1056/nejmoa073770

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TP53 Mutations and Survival in Squamous-Cell Carcinoma of the Head and Neck

Published in New England Journal of Medicine • Dec 19, 2007

Authors:

Maria Luana Poeta

Judith Manola

Meredith A. Goldwasser

Abstract

BACKGROUND: The abrogation of function of the tumor-suppressor protein p53 as a result of mutation of its gene, TP53, is one of the most common genetic alterations in cancer cells. We evaluated TP53 mutations and survival in patients with squamous-cell carcinoma of the head and neck. METHODS: A tota...

Subject

Hazard ratio

Medicine

Mutation

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