Rapid Tachyphylaxis of the Glucagon-Like Peptide 1–Induced Deceleration of Gastric Emptying in Humans

A. Nauck, Michael; Kemmeries, G.; J. Holst, Jens; J. Meier, Juris

doi:10.2337/db10-0474

Public

Rapid Tachyphylaxis of the Glucagon-Like Peptide 1–Induced Deceleration of Gastric Emptying in Humans

Published in Diabetes • Mar 23, 2011

Authors:

Michael A. Nauck

G. Kemmeries

Jens J. Holst

Abstract

OBJECTIVE: Glucagon-like peptide (GLP)-1 lowers postprandial glycemia primarily through inhibition of gastric emptying. We addressed whether the GLP-1-induced deceleration of gastric emptying is subject to rapid tachyphylaxis and if so, how this would alter postprandial glucose control. RESEARCH DES...

Subject

Tachyphylaxis

Gastric emptying

Glucagon

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