SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

A. Malcolm, Bruce; Liu, R.; Lahser, Frederick; Agrawal, Sudhir; Bélanger, Barbara; Butkiewicz, Nancy; A. Chase, Robert; Gheyas, Ferdous; Hart, Andrea; Hesk, David; Ingravallo, Paul; Jiang, Chuan-Kui; Kong, Rong; Lü, Jing; Pichardo, John; Prongay, Andrew; Skelton, Angela; Tong, Xiao; Venkatraman, Srikanth; Xia, Ellen; Girijavallabhan, Viyyoor; George Njoroge, F.

doi:10.1128/aac.50.3.1013-1020.2006

Public

SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

Published in Antimicrobial Agents and Chemotherapy • Feb 22, 2006

Authors:

Bruce A. Malcolm

R. Liu

Frederick Lahser

Abstract

Cleavage of the hepatitis C virus (HCV) polyprotein by the viral NS3 protease releases functional viral proteins essential for viral replication. Recent studies by Foy and coworkers strongly suggest that NS3-mediated cleavage of host factors may abrogate cellular response to alpha interferon (IFN-al...

Subject

Replicon

NS3

Protease

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