A Single-Gene Cause in 29.5% of Cases of Steroid-Resistant Nephrotic Syndrome

E. Sadowski, Carolin; Lovric, Svjetlana; Ashraf, Shazia; L. Pabst, Werner; Yung Gee, Heon; Kohl, Stefan; Engelmann, Susanne; Vega-Warner, Virginia; Fang, Humphrey; Halbritter, Jan; J.G. Somers, Michael; Tan, Weizhen; Shril, Shirlee; Fessi, Inès; P. Lifton, Richard; Böckenhauer, Detlef; M. El-Desoky, Sherif; A. Kari, Jameela; Zenker, Martin; J. Kemper, Markus; Mueller, Dominik; Fathy, Hanan; A. Soliman, Neveen; Hildebrandt, Friedhelm

doi:10.1681/asn.2014050489

Public

A Single-Gene Cause in 29.5% of Cases of Steroid-Resistant Nephrotic Syndrome

Published in Journal of the American Society of Nephrology • Oct 28, 2014

Authors:

Carolin E. Sadowski

Svjetlana Lovric

Shazia Ashraf

Abstract

Steroid-resistant nephrotic syndrome (SRNS) is the second most frequent cause of ESRD in the first two decades of life. Effective treatment is lacking. First insights into disease mechanisms came from identification of single-gene causes of SRNS. However, the frequency of single-gene causation and i...

Subject

Nephrotic syndrome

Age of onset

Genetics

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