A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length

R. Langbehn, Douglas; R. Brinkman, Ryan; Falush, Daniel; S. Paulsen, Jane; R. Hayden, Michael; behalf of an International Huntington's Disease Collaborative Group, on

doi:10.1111/j.1399-0004.2004.00241.x

Public

A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length

Published in Clinical Genetics • Mar 12, 2004

Authors:

Douglas R. Langbehn

Ryan R. Brinkman

Daniel Falush

Abstract

Huntington's disease (HD) is a neurodegenerative disorder caused by an unstable CAG repeat. For patients at risk, participating in predictive testing and learning of having CAG expansion, a major unanswered question shifts from "Will I get HD?" to "When will it manifest?" Using the largest cohort of...

Subject

Penetrance

Age of onset

Cohort

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