The Transcriptional and Epigenomic Foundations of Ground State Pluripotency

Marks, Hendrik; Kalkan, Tüzer; Menafra, Roberta; Denissov, Sergey; D. Jones, Kenneth; Hofemeister, Helmut; Nichols, Jennifer; Kranz, Andrea; Francis Stewart, A.; Smith, Austin; G. Stunnenberg, Hendrik

doi:10.1016/j.cell.2012.03.026

Public

The Transcriptional and Epigenomic Foundations of Ground State Pluripotency

Published in Cell • Apr 1, 2012

Authors:

Hendrik Marks

Tüzer Kalkan

Roberta Menafra

Abstract

Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as "2i" postulated to establish a naive ground state. We show th...

Subject

Biology

Epigenomics

State (computer science)

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