ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

W. Lustbader, Joyce; Cirilli, Maurizio; Lin, Chang; Wei Xu, Hong; Takuma, Kazuhiro; Wang, Ning; Caspersen, Casper; Chen, Xi; Pollak, Susan; Chaney, Michael; Trinchese, Fabrizio; Liu, Shumin; Gunn-Moore, Frank; Lue, Lih-Fen; G. Walker, Douglas; Kuppusamy, Periannan; L. Zewier, Zay; Arancio, Ottavio; Stern, David; ShiDu Yan, Shirley; Wu, Hao

doi:10.1126/science.1091230

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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Shared by NobleBlocks on Apr 16, 2004 • 12:00 AM UTC

Authors:

Joyce W. Lustbader

Maurizio Cirilli

Chang Lin

Abstract

Mitochondrial dysfunction is a hallmark of β-amyloid (Aβ)–induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Aβ-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Aβ to mitochondrial toxicity. Aβ interacts with ABAD in the mitochondria of AD patients a...

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