Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation

Sanulli, Serena; Justin, N.; Teissandier, Aurélie; Ancelin, Katia; Portoso, Manuela; Caron, Matthieu; Michaud, Audrey; Lombard, Bérangère; T. da Rocha, Simao; Offer, John; Loew, Damarys; Servant, Nicolas; Wassef, Michel; Burlina, Fabienne; Gamblin, S.J.; Heard, Édith; Margueron, Raphaël

doi:10.1016/j.molcel.2014.12.020

Public

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation

Published in Molecular Cell • Jan 22, 2015

Authors:

Serena Sanulli

N. Justin

Aurélie Teissandier

Abstract

Polycomb Group (PcG) proteins maintain transcriptional repression throughout development, mostly by regulating chromatin structure. Polycomb Repressive Complex 2 (PRC2), a component of the Polycomb machinery, is responsible for the methylation of histone H3 lysine 27 (H3K27me2/3). Jarid2 was previou...

Subject

Biology

PRC2

Methylation

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