Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of<i>in vitro</i>metabolism using cDNA-expressed human P450s and human liver microsomes

Ono, Satoshi; Hatanaka, T.; Hotta, Hiroshi; Satoh, Takaya; J. Gonzalez, Frank; Tsutsui, Michio

doi:10.3109/00498259609046742

Public

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation ofin vitrometabolism using cDNA-expressed human P450s and human liver microsomes

Published in Xenobiotica • Jan 1, 1996

Authors:

Satoshi Ono

T. Hatanaka

Hiroshi Hotta

Abstract

1. We evaluated the specificity of 15 substrates and 14 inhibitors of the cytochrome P450s using nine human P450 forms expressed in HepG2 cells using a recombinant vaccinia virus and also in human liver microsomes. 2. Coumarin, 7-ethoxyresorufin, 7-benzyloxyresorufin, tolbutamide, aniline and diazep...

Subject

CYP2A6

CYP2B6

Cytochrome P450

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!