Common variants associated with plasma triglycerides and risk for coronary artery disease

Do, Ron; J. Willer, Cristen; M. Schmidt, Ellen; Sengupta, Sebanti; Gao, Chi; M. Peloso, Gina; Gustafsson, Stefan; Kanoni, Stavroula; Ganna, Andrea; Chen, Jin; L. Buchkovich, Martin; Mora, Samia; Beckmann, J.; L. Bragg‐Gresham, Jennifer; Chang, Hsing‐Yi; Demirkan, Ayşe; M. den Hertog, Heleen; A. Donnelly, Louise; Ehret, Georg; Esko, Tõnu; F. Feitosa, Mary; Ferreira, Teresa; Fischer, Krista; Fontanillas, Pierre; M. Fraser, Ross; F. Freitag, Daniel; Gurdasani, Deepti; Heikkilä, Kauko; Hyppönen, Elina; Isaacs, Aaron; Jackson, Anne; Johansson, Åsa; Johnson, Toby; Kaakinen, Marika; Kettunen, Johannes; E. Kleber, Marcus; Li, Xiaohui; Luan, Jian’an; Lyytikäinen, Leo‐Pekka; K. E. Magnusson, Patrik; Mangino, Massimo; Mihailov, Evelin; E. Montasser, May; Müller‐Nurasyid, Martina; M. Nolte, Ilja; R. O’Connell, Jeffrey; D Palmer, Cameron; Perola, Markus; Petersen, Ann-Kristin; Sanna, Serena; Saxena, Richa; K. Service, Susan; Shah, Sonia; Shungin, Dmitry; Sidore, Carlo; Song, Ci; J. Strawbridge, Rona; Surakka, Ida; Tanaka, Toshiko; M. Teslovich, Tanya; Þorleifsson, Guðmar; G. van den Herik, Evita; F. Voight, Benjamin; A. Volcik, Kelly; L. Waite, Lindsay; Wong, Andrew; Wu, Ying; Zhang, Weihua; Absher, Devin; Asiki, Gershim; Barroso, Inês; Been, Latonya; L. Bolton, Jennifer; L. Bonnycastle, Lori; Brambilla, Paolo; Susan Burnett, Mary; Cesana, Giancarlo; Dimitriou, Maria; S. F. Doney, Alex; Döring, Angela; Elliott, Paul; E. Epstein, Stephen; I. Eyjólfsson, Guðmundur; Gigante, Bruna; O. Goodarzi, Mark; Grallert, Harald; L. Gravito, Martha; J. Groves, Christopher; Hallmans, Göran; Hartikainen, Anna-Liisa; Hayward, Caroline; Hernandez, Dena; A. Hicks, Andrew; Hólm, Hilma; Hung, Yi-Jen; Illig, Thomas; R. Jones, Michelle; Kaleebu, Pontiano; J.P. Kastelein, John; Khaw, Kay‐Tee; H. Kim, Eric; Klopp, Norman; Komulainen, Pirjo; Kumari, Meena; Langenberg, Claudia; Lehtimäki, Terho; Lin, Shih-Yi; Lindström, Jaana; J. F. Loos, Ruth; Mach, François; L. McArdle, Wendy; Meisinger, Christa; D. Mitchell, Braxton; Müller, Gabrielle; Nagaraja, Ramaiah; Narisu, Narisu; Nieminen, Tuomo; N. Nsubuga, Rebecca; Ólafsson, Ísleifur; K. Ong, Ken; Palotie, Aarno; Papamarkou, Theodore; Pomilla, Cristina; Pouta, Anneli; J. Rader, Daniel; P. Reilly, Muredach; M. Ridker, Paul; Rivadeneira, Fernando; Rudan, Igor; Ruokonen, Aimo; J. Samani, Nilesh; Scharnagl, Hubert; Seeley, Janet; Silander, Kaisa; Stančáková, Alena; Stirrups, Kathleen; J. Swift, Amy; Tiret, Laurence; G. Uitterlinden, André; Joost van Pelt, L.; Vedantam, Sailaja; W.J. Wainwright, Nicholas; Wijmenga, Cisca; H. Wild, Sarah; Willemsen, Gonneke; Wilsgaard, Tom; F. Wilson, James; Young, Elizabeth; Hua Zhao, Jing; S. Adair, Linda; Arveiler, Dominique; L. Assimes, Themistocles; Bandinelli, Stefania; I. Bennett, Franklyn; Bochud, Murielle; O. Boehm, Bernhard; I. Boomsma, Dorret; B. Borecki, Ingrid; R. Bornstein, Stefan; Bovet, Pascal; Burnier, Michel; Campbell, Harry; Chakravarti, Aravinda; C. Chambers, John; Ida Chen, Yii-Der; S. Collins, Francis; S Cooper, Richard; Danesh, John; Dedoussis, George; dé Fairé, Ulf; B. Feranil, Alan; Ferrières, Jean; Ferrucci, Luigi; B Freimer, Nelson; Gieger, Christian; Groop, Leif; Guðnason, Vilmundur; Gyllensten, Ulf; Hamsten, Anders; B. Harris, Tamara; D. Hingorani, Aroon; N. Hirschhorn, Joel; Hofman, Albert; Kees Hovingh, G.; A. Hsiung, Chao; E. Humphries, Steve; C. Hunt, Steven; Hveem, Kristian; Iribarren, Carlos; Järvelin, Marjo‐Riitta; Jula, Antti; Kähönen, Mika; Kaprio, Jaakko; Kesäniemi, Antero; Kivimäki, Mika; S. Kooner, Jaspal; J. Koudstaal, Peter; M. Krauss, Ronald; Kuh, Diana; Kuusisto, Johanna; Ohm Kyvik, Kirsten; Laakso, Markku; A. Lakka, Timo; Lind, Lars; M. Lindgren, Cecilia; G. Martin, Nicholas; März, Winfried; I. McCarthy, Mark; A. McKenzie, Colin; Meneton, Pierre; Metspalu, Andres; Moilanen, Leena; D. Morris, Andrew; B. Munroe, Patricia; Njølstad, Inger; L. Pedersen, Nancy; Power, Chris; P. Pramstaller, Peter; F. Price, Jackie; M. Psaty, Bruce; Quertermous, Thomas; Rauramaa, Rainer; Saleheen, Danish; Salomaa, Veikko; K. Sanghera, Dharambir; Saramies, Jouko; E. H. Schwarz, Peter; H-H Sheu, Wayne; R. Shuldiner, Alan; Siegbahn, Agneta; D. Spector, Tim; Stefánsson, Kāri; P. Strachan, David; O. Tayo, Bamidele; Tremoli, Elena; Tuomilehto, Jaakko; Uusitupa, Matti; M. van Duijn, Cornelia; Vollenweider, Péter; Wallentin, Lars; J. Wareham, Nicholas; B. Whitfield, John; H. R. Wolffenbuttel, Bruce; Altshuler, David; M. Ordovás, José; Boerwinkle, Eric; N A Palmer, Colin; Þorsteinsdóttir, Unnur; I. Chasman, Daniel; I. Rotter, Jerome; W. Franks, Paul; Ripatti, Samuli; Adrienne Cupples, L.; S. Sandhu, Manjinder; S. Rich, Stephen; Boehnke, Michael; Deloukas, Panos; L. Mohlke, Karen; Ingelsson, Erik; R. Abecasis, Gonçalo; J. Daly, Mark; M. Neale, Benjamin; Kathiresan, Sekar

doi:10.1038/ng.2795

Public

Common variants associated with plasma triglycerides and risk for coronary artery disease

Published in Nature Genetics • Oct 6, 2013

Authors:

Ron Do

Cristen J. Willer

Ellen M. Schmidt

Abstract

Sekar Kathiresan and colleagues examine 185 common variants using a modified mendelian randomization approach and provide evidence supporting a causal role of triglyceride-rich lipoproteins in the development of coronary artery disease. Triglycerides are transported in plasma by specific triglycerid...

Subject

Biology

Coronary artery disease

Internal medicine

Research Assistant

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