Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

Risson, Valérie; Mazelin, Laetitia; Roceri, Mila; Sanchez, Hervé; Moncollin, Vincent; Corneloup, Claudine; Richard‐Bulteau, Hélène; Vignaud, Alban; Baas, Dominique; Defour, Aurélia; Freyssenet, Damien; Tanti, Jean‐François; Le-Marchand-Brustel, Yannick; Ferrier, Bernard; Conjard‐Duplany, Agnès; Romanino, Klaas; Bauché, Stéphanie; Hantaı̈, Daniel; Mueller, Matthias; C. Kozma, Sara; Thomas, George; A. Rüegg, Markus; Ferry, Arnaud; Pende, Mario; Bigard, Xavier; Koulmann, Nathalie; Schaeffer, Laurent; Gangloff, Yann‐Gaël

doi:10.1083/jcb.200903131

Public

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

Published in The Journal of Cell Biology • Dec 14, 2009

Authors:

Valérie Risson

Laetitia Mazelin

Mila Roceri

Abstract

Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively. Raptor is required for oxidative muscle integrity, whereas rictor is dispensable. In this study, we show that muscle-specific in...

Subject

mTORC2

PI3K/AKT/mTOR pathway

mTORC1

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