Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation

C. Yeung, Kam; W. Rose, David; S. Dhillon, Amardeep; Yaros, Diane; K. Gustafsson, Marcus; Chatterjee, Devasis; W. McFerran, Brian; H. Wyche, James; Kölch, Walter; M. Sedivy, John

doi:10.1128/mcb.21.21.7207-7217.2001

Public

Raf Kinase Inhibitor Protein Interacts with NF-κB-Inducing Kinase and TAK1 and Inhibits NF-κB Activation

Published in Molecular and Cellular Biology • Nov 1, 2001

Authors:

Kam C. Yeung

David W. Rose

Amardeep S. Dhillon

Abstract

The Raf kinase inhibitor protein (RKIP) acts as a negative regulator of the mitogen-activated protein (MAP) kinase (MAPK) cascade initiated by Raf-1. RKIP inhibits the phosphorylation of MAP/extracellular signal-regulated kinase 1 (MEK1) by Raf-1 by disrupting the interaction between these two kinas...

Subject

Biology

MAP kinase kinase kinase

Kinase

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