Nogo Receptor 1 (RTN4R) as a Candidate Gene for Schizophrenia: Analysis Using Human and Mouse Genetic Approaches

Hsu, Ruby; Woodroffe, Abigail; Lai, Wen‐Sung; N. Cook, Melloni; Mukai, Jun; P. Dunning, Jonathan; J. Swanson, Douglas; L. Roos, Johannes; R. Abecasis, Gonçalo; Karayiorgou, Maria; A. Gogos, Joseph

doi:10.1371/journal.pone.0001234

Public

Nogo Receptor 1 (RTN4R) as a Candidate Gene for Schizophrenia: Analysis Using Human and Mouse Genetic Approaches

Published in PLoS ONE • Nov 27, 2007

Authors:

Ruby Hsu

Abigail Woodroffe

Wen‐Sung Lai

Abstract

BACKGROUND: NOGO Receptor 1 (RTN4R) regulates axonal growth, as well as axon regeneration after injury. The gene maps to the 22q11.2 schizophrenia susceptibility locus and is thus a strong functional and positional candidate gene. METHODOLOGY/PRINCIPAL FINDINGS: We evaluate evidence for genetic asso...

Subject

Haploinsufficiency

Schizophrenia (object-oriented programming)

Candidate gene

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