Tamoxifen Resistance in Breast Tumors Is Driven by Growth Factor Receptor Signaling with Repression of Classic Estrogen Receptor Genomic Function

Massarweh, Suleiman; Kent Osborne, C.; J. Creighton, Chad; Qin, Lanfang; Tsimelzon, Anna; Huang, Shixia; L. Weiss, Heidi; F. Rimawi, Mothaffar; Schiff, Rachel

doi:10.1158/0008-5472.can-07-2707

Public

Tamoxifen Resistance in Breast Tumors Is Driven by Growth Factor Receptor Signaling with Repression of Classic Estrogen Receptor Genomic Function

Published in Cancer Research • Feb 1, 2008

Authors:

Suleiman Massarweh

C. Kent Osborne

Chad J. Creighton

Abstract

Not all breast cancers respond to tamoxifen, and many develop resistance despite initial benefit. We used an in vivo model of estrogen receptor (ER)-positive breast cancer (MCF-7 xenografts) to investigate mechanisms of this resistance and develop strategies to circumvent it. Epidermal growth factor...

Subject

Tamoxifen

Gefitinib

Estrogen receptor

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