Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithelial-to-Mesenchymal Transition Mediated by NF-κB and Snail

Jung Kim, Hyun; C. Litzenburger, Beate; Cui, Xiaojiang; A. Delgado, David; C. Grabiner, Brian; Lin, Xin; T. Lewis, Michael; M. Gottardis, Marco; W. Wong, Tai; M. Attar, Ricardo; M. Carboni, Joan; V. Lee, Adrian

doi:10.1128/mcb.01315-06

Public

Constitutively Active Type I Insulin-Like Growth Factor Receptor Causes Transformation and Xenograft Growth of Immortalized Mammary Epithelial Cells and Is Accompanied by an Epithelial-to-Mesenchymal Transition Mediated by NF-κB and Snail

Published in Molecular and Cellular Biology • Feb 12, 2007

Authors:

Hyun Jung Kim

Beate C. Litzenburger

Xiaojiang Cui

Abstract

Type I insulin-like growth factor receptor (IGF-IR) can transform mouse fibroblasts; however, little is known about the transforming potential of IGF-IR in human fibroblasts or epithelial cells. We found that overexpression of a constitutively activated IGF-IR (CD8-IGF-IR) was sufficient to cause tr...

Subject

Biology

Epithelial–mesenchymal transition

Downregulation and upregulation

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