Neoadjuvant Chemotherapy With High-Dose Ifosfamide, High-Dose Methotrexate, Cisplatin, and Doxorubicin for Patients With Localized Osteosarcoma of the Extremity: A Joint Study by the Italian and Scandinavian Sarcoma Groups

Ferrari, Stefano; Smeland, Sigbjørn; Mercuri, Mario; Bertoni, Franco; Longhi, Alessandra; Ruggieri, Pietro; Alvegård, Thor; Picci, Piero; Capanna, Rodolfo; Bernini, Gabriella; Müller, Cristoph; Tienghi, A.; Wiebe, Thomas; Comandone, Alessandro; Böhling, Tom; Brach del Prever, Adalberto; Brosjö, Otte; Bacci, Gaetano; Sæter, Gunnar

doi:10.1200/jco.2004.00.5785

Public

Neoadjuvant Chemotherapy With High-Dose Ifosfamide, High-Dose Methotrexate, Cisplatin, and Doxorubicin for Patients With Localized Osteosarcoma of the Extremity: A Joint Study by the Italian and Scandinavian Sarcoma Groups

Published in Journal of Clinical Oncology • Oct 26, 2005

Authors:

Stefano Ferrari

Sigbjørn Smeland

Mario Mercuri

Abstract

PURPOSE: To explore the effect of high-dose ifosfamide in first-line treatment for patients < or = 40 years of age with nonmetastatic osteosarcoma of the extremity. PATIENTS AND METHODS: From March 1997 to September 2000, 182 patients were evaluated. Primary treatment consisted of two blocks of high...

Subject

Ifosfamide

Medicine

Osteosarcoma

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