Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130.

G Zhang, X; Gu, Jianlai; Lu, Zhao‐Yang; Yasukawa, Kiyoshi; D. Yancopoulos, George; J. Turner, Katherine; Shoyab, M.; Taga, Tetsuya; Kishimoto, Tadamitsu; Bataille, Régis

doi:10.1084/jem.179.4.1337

Public

Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130.

Published in The Journal of Experimental Medicine • Apr 1, 1994

Authors:

X G Zhang

Jianlai Gu

Zhao‐Yang Lu

Abstract

Interleukin 6 (IL-6) is a major growth factor for tumor plasma cells involved in human multiple myeloma (MM). In particular, human myeloma cell lines (HMCL), whose growth is completely dependent on addition of exogenous IL-6, can be obtained reproducibly from every patient with terminal disease. Fou...

Subject

Oncostatin M

Leukemia inhibitory factor receptor

Glycoprotein 130

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